Sobre el grupo
Investigador Principal
Cristina Paules TejeroEquipo
Ana Medel Martínez, Jesús González Pérez, Natalia Abadía Cuchí, Pilar Maestro Quibus, Sonia Ruiz Lorente
Hospital Clínico Universitario Lozano Blesa
Líneas de Investigación
Amenaza de parto prematuro
Diabetes gestacional
Programación fetal
Publicaciones mas relevantes
González J, Vilella M, Ruiz S, Iglesia I, Clavero-Adell M, Ayerza-Casas A, Matute-Llorente A, Oros D, Casajús JA, Pueyo V, Rodriguez G, Paules C. Impact of Suspected Preterm Labor during Pregnancy on Cardiometabolic Profile and Neurodevelopment during Childhood: A Prospective Cohort Study Protocol. Diagnostics (Basel). 2023 Mar 14;13(6):1101. doi: 10.3390/diagnostics13061101. PMID: 36980410; PMCID: PMC10047113.
Fabre M, Calvo P, Ruiz-Martinez S, Peran M, Oros D, Medel-Martinez A, Strunk M, Benito Ruesca R, Schoorlemmer J, Paules C. Frequent Placental SARS-CoV-2 in Patients with COVID-19-Associated Hypertensive Disorders of Pregnancy. Fetal Diagn Ther. 2021;48(11-12):801-811. doi: 10.1159/000520179. Epub 2021 Nov 18. PMID: 34794139; PMCID: PMC8678236.
Abadía-Cuchí N, Ruiz-Martínez S, Fabre M, Mateo P, Remacha Sienes M, Ventura Faci P, Bueno Sancho J, Benito R, Paules C. SARS-CoV-2 congenital infection and pre-eclampsia-like syndrome in dichorionic twins: A case report and review of the literature. Int J Gynaecol Obstet. 2021 Aug;154(2):370-372. doi: 10.1002/ijgo.13749. Epub 2021 Jun 9. PMID: 34009656; PMCID: PMC9087521.
Medel-Martínez A, Paules C, Perán M, Calvo P, Ruiz-Martinez S, Ormazabal Cundin M, Cebollada-Solanas A, Strunk M, Schoorlemmer J, Oros D, Fabre M. “Placental infection associated with SARS-CoV-2 wildtype variant and variants of concern”. Manuscript submitted.
Ruiz-Martinez, S.; Delgado, J. L.; Paules, C.; Cavallaro, A.; De Paco, C.; Villar, J.; Papageorghiou, A.; Oros, D.Clinical phenotypes for risk stratification in small-for-gestational-age fetuses. ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 59, 2022. ISSN 0960-7692
Paules, Cristina; Perez Roche, Maria Teresa; Angel Marin, Miguel; Fayed, Nicolas; Garcia-Marti, Gracian; Lopez Pison, Javier; Oros, Daniel; Pueyo, Victoria. Different Brain Phenotypes in Magnetic Resonance Imaging of Healthy Children after Prenatal Insults. DIAGNOSTICS. 12, 2022.
Basso, A.; Youssef, L.; Nakaki, A.; Paules, C.; Miranda, J.; Casu, G.; Salazar, L.; Gratacos, E.; Eixarch, E.; Crispi, F.; Crovetto, F.. Fetal neurosonography at 31-35 weeks reveals altered cortical development in pre-eclampsia with and without small-for-gestational-age fetus. ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 59, 2022. ISSN 0960-7692 DOI: 10.1002/uog.24853
Youssef, Lina; Crovetto, Francesca; Simoes, Rui Vasco; Miranda, Jezid; Paules, Cristina; Blasco, Miquel; Palomo, Marta; Garcia-Caldero, Hector; Tura-Ceide, Olga; Dantas, Ana Paula; Hernandez-Gea, Virginia; Herrero, Pol; Canela, Nuria; Campistol, Josep Maria; Garcia-Pagan, Joan Carles; Diaz-Ricart, Maribel; Gratacos, Eduard; Crispi, Fatima. The Interplay between Pathophysiological Pathways in Early-Onset Severe Preeclampsia Unveiled by Metabolomics. LIFE-BASEL. 12, 2022. DOI: 10.3390/life12010086
Cobo, Teresa; Aldecoa, Victoria; Bartha, Jose Luis; Bugatto, Fernando; Carrillo-Badillo, Maria Paz; Comas, Carmina; Diago-Almeda, Vicente; Ferrero, Silvia; Goya, Maria; Herraiz, Ignacio; Marti-Malgosa, Laia; Olivella, Anna; Paules, Cristina; Vives, Angels; Figueras, Francesc; Palacio, Montse; Gratacos, Eduard; OPTIM-PTL Grp. Assessment of an intervention to optimise antenatal management of women admitted with preterm labour and intact membranes using amniocentesis-based predictive risk models: study protocol for a randomised controlled trial (OPTIM-PTL Study). BMJ OPEN. 11, 2021. ISSN 2044-6055. DOI: 10.1136/bmjopen-2021-054711
Youssef, Lina; Miranda, Jezid; Blasco, Miquel; Paules, Cristina; Crovetto, Francesca; Palomo, Marta; Torramade-Moix, Sergi; Garcia-Caldero, Hector; Tura-Ceide, Olga; Paula Dantas, Ana; Hernandez-Gea, Virginia; Herrero, Pol; Canela, Nuria; Maria Campistol, Josep; Carles Garcia-Pagan, Joan; Diaz-Ricart, Maribel; Gratacos, Eduard; Crispi, Fatima. Complement and coagulation cascades activation is the main pathophysiological pathway in early-onset severe preeclampsia revealed by maternal proteomics. SCIENTIFIC REPORTS. 11, 2021. ISSN 2045-2322 DOI: 10.1038/s41598-021-82733-z
Crovetto F; Crispi F; Casas R; Martín-Asuero A; Borràs R; Vieta E; Estruch R; Gratacós E; IMPACT BCN Trial Investigators. Effects of Mediterranean Diet or Mindfulness-Based Stress Reduction on Prevention of Small-for-Gestational Age Birth Weights in Newborns Born to At-Risk Pregnant Individuals: The IMPACT BCN Randomized Clinical Trial.JAMA. 326, pp. 2150 - 2160. 2021. ISSN 0098-7484 DOI: 10.1001/jama.2021.20178
Paules, C.; Miranda, J.; Policiano, C.; Crovetto, F.; Youssef, L.; Hahner, N.; Nakaki, A.; Crispi, F.; Gratacos, E.; Eixarch, E.. Fetal neurosonography detects differences in cortical development and corpus callosum in late-onset small fetuses. ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 58, 2021. ISSN 0960-7692. DOI: 10.1002/uog.23592
Crovetto, Francesca; Crispi, Fatima; Borras, Roger; Paules, Cristina; Casas, Rosa; Martin-Asuero, Andres; Arranz, Angela; Vieta, Eduard; Estruch, Ramon; Gratacos, Eduard. Mediterranean diet, Mindfulness-Based Stress Reduction and usual care during pregnancy for reducing fetal growth restriction and adverse perinatal outcomes: IMPACT BCN (Improving Mothers for a better PrenAtal Care Trial BarCeloNa): a study protocol for a randomized controlled trial. TRIALS. 22, 2021.
Youssef, Lina; Simoes, Rui V.; Miranda, Jezid; Garcia-Martin, Maria Luisa; Paules, Cristina; Crovetto, Francesca; Amigo, Nuria; Canellas, Nicolau; Gratacos, Eduard; Crispi, Fatima. Paired maternal and fetal metabolomics reveal a differential fingerprint in preeclampsia versus fetal growth restriction. SCIENTIFIC REPORTS. 11, 2021. ISSN 2045-2322
Schoorlemmer, Jon; Macias-Redondo, Sofia; Strunk, Mark; Ramos-Ruiz, Ricardo; Calvo, Pilar; Benito, Rafael; Paules, Cristina; Oros, Daniel. Altered DNA methylation in human placenta after (suspected) preterm labor. EPIGENOMICS. 12, 2020. ISSN 1750-1911 DOI: 10.2217/epi-2019-0346
Youssef, Lina; Erlandsson, Lena; Akerstrom, Bo; Miranda, Jezid; Paules, Cristina; Crovetto, Francesca; Crispi, Fatima; Gratacos, Eduard; Hansson, Stefan R.. Hemopexin and alpha(1)-microglobulin heme scavengers with differential involvement in preeclampsia and fetal growth restriction. PLOS ONE. 15, 2020. ISSN 1932-6203 DOI: 10.1371/journal.pone.0239030
Paules, Cristina; Youssef, Lina; Miranda, Jezid; Crovetto, Francesca; Maria Estanyol, Josep; Fernandez, Guerau; Crispi, Fatima; Gratacos, Eduard. Maternal proteomic profiling reveals alterations in lipid metabolism in late-onset fetal growth restriction. SCIENTIFIC REPORTS. 10, 2020. ISSN 2045-2322
Lou-Mercade, A. C.; Gavin, O.; Oros, D.; Paules, C.; Saviron-Cornudella, R.; Mateo, P.; Paramo, J. A.; Ruiz-Martinez, S.. Prevention of thrombosis in pregnant women with suspected SARS-CoV-2 infection: clinical management algorithm. ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 56, 2020. ISSN 0960-7692. DOI: 10.1002/uog.22096
Quintana LF; Palomo M; Blasco M; Molina P; Lozano M; Praga M; Torramade-Moix S; Martinez-Sanchez J; Cid J; Escolar G; Carreras E; Paules C; Crispi F; Poch E; Rodas L; Goma E; Morelle J; Espinosa M; Morales E; Avila A; Cabello V; Ariceta G; Chocron S; Manrique J; Barros X; Martin N; Huerta A; Fraga-Rodriguez GM; Cao M; Martin M; Romera AM; Moreso F; Manonelles A; Gratacos E; Pereira A; Campistol JM; Diaz-Ricart M. Complement Activation and Thrombotic Microangiopathies. Clin J Am Soc Nephrol.14 - 12, pp. 1719 - 1732. 12/2019. ISSN 1555-9041 DOI: 10.2215/CJN.05830519
Youssef L; Miranda J; Paules C; Garcia-Otero L; Vellve K; Kalapotharakos G; Sepulveda-Martinez A; Crovetto F; Gomez O; Gratacos E; Crispi F. Fetal cardiac remodeling and dysfunction is associated with both preeclampsia and fetal growth restriction. Am J Obstet Gynecol. 07/2019. DOI: doi: 10.1016/j.ajog.2019.07.025
Cristina Paules Tejero; Youssef L; Rovira C; Crovetto F; Nadal A; Peguero A; Figueras F; Eixarch E; Crispi f; Miranda J; Gratacos E. Distinctive patterns of placental lesions in preeclampsia versus fetal growth restriction and their association with fetoplacental Doppler. Ultrasound Obst Gyn. 05/2019.
Miranda J; Simoes R; Cristina Paules Tejero; Canueto D; Pardo-Cea M; Garcia-Martin ML; Crovetto F; Fuertes-Martin R; Domenech M; Gomez-Roig MD; Eixarch E; Estruch R; Hansson S; Amigo N; Canellas N; Crispi F; Gratacos E. Metabolic profiling and targeted lipidomics reveals a disturbed lipid profile in mothers and fetuses with intrauterine growth restriction.Sci Rep-UK. 09/2018. DOI: 10.1038/s41598-018-31832-5
Fabre M, Calvo P, Ruiz-Martinez S, Peran M, Oros D, Medel-Martinez A, Strunk M, Benito Ruesca R, Schoorlemmer J, Paules C. Frequent Placental SARS-CoV-2 in Patients with COVID-19-Associated Hypertensive Disorders of Pregnancy. Fetal Diagn Ther. 2021;48(11-12):801-811. doi: 10.1159/000520179. Epub 2021 Nov 18. PMID: 34794139; PMCID: PMC8678236.
Abadía-Cuchí N, Ruiz-Martínez S, Fabre M, Mateo P, Remacha Sienes M, Ventura Faci P, Bueno Sancho J, Benito R, Paules C. SARS-CoV-2 congenital infection and pre-eclampsia-like syndrome in dichorionic twins: A case report and review of the literature. Int J Gynaecol Obstet. 2021 Aug;154(2):370-372. doi: 10.1002/ijgo.13749. Epub 2021 Jun 9. PMID: 34009656; PMCID: PMC9087521.
Medel-Martínez A, Paules C, Perán M, Calvo P, Ruiz-Martinez S, Ormazabal Cundin M, Cebollada-Solanas A, Strunk M, Schoorlemmer J, Oros D, Fabre M. “Placental infection associated with SARS-CoV-2 wildtype variant and variants of concern”. Manuscript submitted.
Ruiz-Martinez, S.; Delgado, J. L.; Paules, C.; Cavallaro, A.; De Paco, C.; Villar, J.; Papageorghiou, A.; Oros, D.Clinical phenotypes for risk stratification in small-for-gestational-age fetuses. ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 59, 2022. ISSN 0960-7692
Paules, Cristina; Perez Roche, Maria Teresa; Angel Marin, Miguel; Fayed, Nicolas; Garcia-Marti, Gracian; Lopez Pison, Javier; Oros, Daniel; Pueyo, Victoria. Different Brain Phenotypes in Magnetic Resonance Imaging of Healthy Children after Prenatal Insults. DIAGNOSTICS. 12, 2022.
Basso, A.; Youssef, L.; Nakaki, A.; Paules, C.; Miranda, J.; Casu, G.; Salazar, L.; Gratacos, E.; Eixarch, E.; Crispi, F.; Crovetto, F.. Fetal neurosonography at 31-35 weeks reveals altered cortical development in pre-eclampsia with and without small-for-gestational-age fetus. ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 59, 2022. ISSN 0960-7692 DOI: 10.1002/uog.24853
Youssef, Lina; Crovetto, Francesca; Simoes, Rui Vasco; Miranda, Jezid; Paules, Cristina; Blasco, Miquel; Palomo, Marta; Garcia-Caldero, Hector; Tura-Ceide, Olga; Dantas, Ana Paula; Hernandez-Gea, Virginia; Herrero, Pol; Canela, Nuria; Campistol, Josep Maria; Garcia-Pagan, Joan Carles; Diaz-Ricart, Maribel; Gratacos, Eduard; Crispi, Fatima. The Interplay between Pathophysiological Pathways in Early-Onset Severe Preeclampsia Unveiled by Metabolomics. LIFE-BASEL. 12, 2022. DOI: 10.3390/life12010086
Cobo, Teresa; Aldecoa, Victoria; Bartha, Jose Luis; Bugatto, Fernando; Carrillo-Badillo, Maria Paz; Comas, Carmina; Diago-Almeda, Vicente; Ferrero, Silvia; Goya, Maria; Herraiz, Ignacio; Marti-Malgosa, Laia; Olivella, Anna; Paules, Cristina; Vives, Angels; Figueras, Francesc; Palacio, Montse; Gratacos, Eduard; OPTIM-PTL Grp. Assessment of an intervention to optimise antenatal management of women admitted with preterm labour and intact membranes using amniocentesis-based predictive risk models: study protocol for a randomised controlled trial (OPTIM-PTL Study). BMJ OPEN. 11, 2021. ISSN 2044-6055. DOI: 10.1136/bmjopen-2021-054711
Youssef, Lina; Miranda, Jezid; Blasco, Miquel; Paules, Cristina; Crovetto, Francesca; Palomo, Marta; Torramade-Moix, Sergi; Garcia-Caldero, Hector; Tura-Ceide, Olga; Paula Dantas, Ana; Hernandez-Gea, Virginia; Herrero, Pol; Canela, Nuria; Maria Campistol, Josep; Carles Garcia-Pagan, Joan; Diaz-Ricart, Maribel; Gratacos, Eduard; Crispi, Fatima. Complement and coagulation cascades activation is the main pathophysiological pathway in early-onset severe preeclampsia revealed by maternal proteomics. SCIENTIFIC REPORTS. 11, 2021. ISSN 2045-2322 DOI: 10.1038/s41598-021-82733-z
Crovetto F; Crispi F; Casas R; Martín-Asuero A; Borràs R; Vieta E; Estruch R; Gratacós E; IMPACT BCN Trial Investigators. Effects of Mediterranean Diet or Mindfulness-Based Stress Reduction on Prevention of Small-for-Gestational Age Birth Weights in Newborns Born to At-Risk Pregnant Individuals: The IMPACT BCN Randomized Clinical Trial.JAMA. 326, pp. 2150 - 2160. 2021. ISSN 0098-7484 DOI: 10.1001/jama.2021.20178
Paules, C.; Miranda, J.; Policiano, C.; Crovetto, F.; Youssef, L.; Hahner, N.; Nakaki, A.; Crispi, F.; Gratacos, E.; Eixarch, E.. Fetal neurosonography detects differences in cortical development and corpus callosum in late-onset small fetuses. ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 58, 2021. ISSN 0960-7692. DOI: 10.1002/uog.23592
Crovetto, Francesca; Crispi, Fatima; Borras, Roger; Paules, Cristina; Casas, Rosa; Martin-Asuero, Andres; Arranz, Angela; Vieta, Eduard; Estruch, Ramon; Gratacos, Eduard. Mediterranean diet, Mindfulness-Based Stress Reduction and usual care during pregnancy for reducing fetal growth restriction and adverse perinatal outcomes: IMPACT BCN (Improving Mothers for a better PrenAtal Care Trial BarCeloNa): a study protocol for a randomized controlled trial. TRIALS. 22, 2021.
Youssef, Lina; Simoes, Rui V.; Miranda, Jezid; Garcia-Martin, Maria Luisa; Paules, Cristina; Crovetto, Francesca; Amigo, Nuria; Canellas, Nicolau; Gratacos, Eduard; Crispi, Fatima. Paired maternal and fetal metabolomics reveal a differential fingerprint in preeclampsia versus fetal growth restriction. SCIENTIFIC REPORTS. 11, 2021. ISSN 2045-2322
Schoorlemmer, Jon; Macias-Redondo, Sofia; Strunk, Mark; Ramos-Ruiz, Ricardo; Calvo, Pilar; Benito, Rafael; Paules, Cristina; Oros, Daniel. Altered DNA methylation in human placenta after (suspected) preterm labor. EPIGENOMICS. 12, 2020. ISSN 1750-1911 DOI: 10.2217/epi-2019-0346
Youssef, Lina; Erlandsson, Lena; Akerstrom, Bo; Miranda, Jezid; Paules, Cristina; Crovetto, Francesca; Crispi, Fatima; Gratacos, Eduard; Hansson, Stefan R.. Hemopexin and alpha(1)-microglobulin heme scavengers with differential involvement in preeclampsia and fetal growth restriction. PLOS ONE. 15, 2020. ISSN 1932-6203 DOI: 10.1371/journal.pone.0239030
Paules, Cristina; Youssef, Lina; Miranda, Jezid; Crovetto, Francesca; Maria Estanyol, Josep; Fernandez, Guerau; Crispi, Fatima; Gratacos, Eduard. Maternal proteomic profiling reveals alterations in lipid metabolism in late-onset fetal growth restriction. SCIENTIFIC REPORTS. 10, 2020. ISSN 2045-2322
Lou-Mercade, A. C.; Gavin, O.; Oros, D.; Paules, C.; Saviron-Cornudella, R.; Mateo, P.; Paramo, J. A.; Ruiz-Martinez, S.. Prevention of thrombosis in pregnant women with suspected SARS-CoV-2 infection: clinical management algorithm. ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 56, 2020. ISSN 0960-7692. DOI: 10.1002/uog.22096
Quintana LF; Palomo M; Blasco M; Molina P; Lozano M; Praga M; Torramade-Moix S; Martinez-Sanchez J; Cid J; Escolar G; Carreras E; Paules C; Crispi F; Poch E; Rodas L; Goma E; Morelle J; Espinosa M; Morales E; Avila A; Cabello V; Ariceta G; Chocron S; Manrique J; Barros X; Martin N; Huerta A; Fraga-Rodriguez GM; Cao M; Martin M; Romera AM; Moreso F; Manonelles A; Gratacos E; Pereira A; Campistol JM; Diaz-Ricart M. Complement Activation and Thrombotic Microangiopathies. Clin J Am Soc Nephrol.14 - 12, pp. 1719 - 1732. 12/2019. ISSN 1555-9041 DOI: 10.2215/CJN.05830519
Youssef L; Miranda J; Paules C; Garcia-Otero L; Vellve K; Kalapotharakos G; Sepulveda-Martinez A; Crovetto F; Gomez O; Gratacos E; Crispi F. Fetal cardiac remodeling and dysfunction is associated with both preeclampsia and fetal growth restriction. Am J Obstet Gynecol. 07/2019. DOI: doi: 10.1016/j.ajog.2019.07.025
Cristina Paules Tejero; Youssef L; Rovira C; Crovetto F; Nadal A; Peguero A; Figueras F; Eixarch E; Crispi f; Miranda J; Gratacos E. Distinctive patterns of placental lesions in preeclampsia versus fetal growth restriction and their association with fetoplacental Doppler. Ultrasound Obst Gyn. 05/2019.
Miranda J; Simoes R; Cristina Paules Tejero; Canueto D; Pardo-Cea M; Garcia-Martin ML; Crovetto F; Fuertes-Martin R; Domenech M; Gomez-Roig MD; Eixarch E; Estruch R; Hansson S; Amigo N; Canellas N; Crispi F; Gratacos E. Metabolic profiling and targeted lipidomics reveals a disturbed lipid profile in mothers and fetuses with intrauterine growth restriction.Sci Rep-UK. 09/2018. DOI: 10.1038/s41598-018-31832-5
Otra actividad
Proyectos:
“Impacto de la amenaza de parto prematuro en la programación cardiovascular y metabólica desde la vida fetal hasta la infancia”. Instituto de Investigación Sanitaria Carlos III (PI20/00741).
Valoración global de salud en la infancia tras sufrir una amenaza de parto pretérmino “Superkids study”.
Caracterización fenotípica de la diabetes gestacional: abordaje personalizado de las complicaciones materno-fetales a corto y medio plazo (Pheno-GestDM). Solicitado en esta convocatoria Proyectos de I+D+I en salud. (AES 2023)
Tesis:
La IP dirige la tesis doctoral de Ana Medel, Jesús González y Natalia Abadía.
“Impacto de la amenaza de parto prematuro en la programación cardiovascular y metabólica desde la vida fetal hasta la infancia”. Instituto de Investigación Sanitaria Carlos III (PI20/00741).
Valoración global de salud en la infancia tras sufrir una amenaza de parto pretérmino “Superkids study”.
Caracterización fenotípica de la diabetes gestacional: abordaje personalizado de las complicaciones materno-fetales a corto y medio plazo (Pheno-GestDM). Solicitado en esta convocatoria Proyectos de I+D+I en salud. (AES 2023)
Tesis:
La IP dirige la tesis doctoral de Ana Medel, Jesús González y Natalia Abadía.