Sobre el grupo


Investigador Principal

Gracia María Mendoza Cantos

Equipo

Cristina Remirez de Ganuza Rodrigo, Enrique Gámez Herrera, Guillermo Landa Baila, Iman Mattar, Mª Mar Encabo Berzosa, Manuel Arruebo Gordo, María Cristina Yus Argón, Marina Frutos Lizano, Mónica Paesa Morales, Natalia Victoria Izquierdo Brusau

Edificio CIBA

Líneas de Investigación


Sistemas de liberación controlada de fármacos y moléculas terapéuticas

Materiales antimicrobianos y su validación in vitro e in vivo

Sistemas de fabricación de andamios para ingeniería de tejidos e implantes

Desarrollo de dispositivos médicos combinatoriales


Publicaciones más relevantes


- “New insights in osteoarthritis diagnosis and treatment: Nano-strategies for an improved disease treatment” Monica Paesa, Teresa Alejo, Felicito García-Alvarez, Manuel Arruebo, Gracia Mendoza. WIREs Nanomedicine and Nanobiotechnology 2022. Q1.

- “Pharmacokinetic control on the release of antimicrobial drugs from pH-responsive electrospun wound dressings” Laura G. Miranda-Calderón, Cristina Yus, Guillermo Landa, Gracia Mendoza, Manuel Arruebo, Silvia Irusta. International Journal of Pharmaceutics 624: 122003. 2022. Q1.

- “Valorization of phenolic compounds obtained from onion waste and their application in colon cancer” Mónica Paesa, Danielle Pires Nogueira, Gustavo Velderrain-Rodríguez, Irene Esparza, Nerea Jiménez-Moreno, Gracia Mendoza, Jesús Osada, Olga Martin-Belloso, Maria Jesús Rodríguez-Yoldi, Carmen Ancín-Azpilicueta. Antioxidants 11:733. 2022. D1.

- “Microfluidic synthesis of block copolymer micelles: application as drug nanocarriers and as photothermal transductors when loading Pd nanosheets” Miriam Abad, Gracia Mendoza, Laura Usón, Manuel Arruebo, Milagros Piñol, Victor Sebastian, Luis Oriol. Macromolecular Bioscience. 2022. Q1.

- "Light activated pulsatile drug delivery for prolonged peripheral nerve block” Martín Prieto, Laura Usón, Sara García-Salinas, Cristina Yus, Guillermo Landa, Teresa Alejo, Lluís Luján, Marta Pérez, Silvia Irusta, Víctor Sebastián, Gracia Mendoza, Manuel Arruebo. Biomaterials 283:121453. 2022. D1.

- “On the role of components of therapeutic hydrophobic deep eutectic solvent-based nanoemulsions produced by membrane-assisted nanoemulsification for enhanced antimicrobial activity” Usman T. Syed, Inês C. Leonardo, Gracia Mendoza, Frédéric B. Gaspar, Enrique Gámez, Rosa M. Huertas, Maria T.B. Crespo, Manuel Arruebo, João G. Crespo, Victor Sebastian, Carla Brazinha. Separation and Purification Technology 285:120319. 2022. D1.

- “Hybrid thermoresponsive nanoparticles containing drug nanocrystals for NIR-triggered remote release” Teresa Alejo, Victor Sebastian, Gracia Mendoza, Manuel Arruebo. Journal of Colloid and Interface Science 607:1466. 2022. Q1.

- “Nanoengineering palladium plasmonic nanosheets inside polymer nanospheres for photothermal therapy and targeted drug delivery” Laura Usón, Cristina Yus, Gracia Mendoza, Eric Leroy, Silvia Irusta, Teresa Alejo, David Garcia-Domingo, Ane Larrea, Manuel Arruebo, Raúl Arenal, Víctor Sebastián. Advanced Functional Materials 2106932. 2022. D1.

- “Submicronic filtering media based on electrospun recycled PET nanofibers: Development, characterization, and method to manufacture surgical mask” Marta Baselga-Lahoz, Cristina Yus, Manuel Arruebo, Víctor Sebastián, Silvia Irusta, Santiago Jiménez. Nanomaterials 12:925. 2022. Q1.

- “The reversion of osteoarthritis-like alterations by raloxifene and phloretin in lipopolysaccharide-induced chondrogenic cell lines” Mónica Paesa, Cristina Remírez de Ganuza, Felícito García-Álvarez, Silvia Irusta, Manuel Arruebo, Gracia Mendoza. Osteoarthritis & Cartilage 30:S430. 2022. D1.

- “Ipriflavone-loaded poly(D,L-lactide-co-glycolide) acid nanoparticles for the treatment of osteoarthritis” Cristina Remírez de Ganuza, Mónica Paesa, Felícito García-Álvarez, María Jesús Rodríguez-Yoldi, Silvia Irusta, Manuel Arruebo, Gracia Mendoza. Osteoarthritis & Cartilage 30:S84-S85. 2022. D1.

- “Therapeutic molecules for osteoarthritis treatment. Role of phloretin, ipriflavone and raloxifene in lipopolysaccharide induced osteoarthritic chondrocytes” Mónica Paesa, Cristina Remírez de Ganuza, Jorge Bertol, Felícito García-Álvarez, María Jesús Rodríguez-Yoldi, Silvia Irusta, Manuel Arruebo, Gracia Mendoza. Osteoarthritis & Cartilage 29, 2021. D1.

- “Evaluation of osteoarthritis biomarkers from patients derived explants. Differences between healthy and osteoarthritic cartilage” Mónica Paesa, Cristina Remírez de Ganuza, Jorge Bertol, Felícito García-Álvarez, María Jesús Rodríguez-Yoldi, Silvia Irusta, Manuel Arruebo, Gracia Mendoza. Osteoarthritis & Cartilage 29, 2021. D1.

- “Chalcogenide nanoparticles and organic photosensitizers for synergetic antimicrobial photodynamic therapy” Carlos Garin, Teresa Alejo, Vanessa Perez-Laguna, Martin Prieto, Gracia Mendoza, Manuel Arruebo, Victor Sebastian, Antonio Rezusta. Journal of Materials Chemistry B 9:6246. 2021. Q1.

- “Selective point-of-care detection of pathogenic bacteria using sialic acid functionalized gold nanoparticles” Guillermo Landa, Laura Miranda-Calderón, Victor Sebastian, Silvia Irusta, Gracia Mendoza, Manuel Arruebo. Talanta 234:122644. 2021. Q1.

- “Nanogels with high loading of anesthetic nanocrystals for extended duration of sciatic nerve block” Teresa Alejo, Laura Uson, Guillermo Landa, Martin Prieto, Cristina Yus, Sara Garcia-Salinas, Ricardo de Miguel, Ana Rodríguez-Largo, Silvia Irusta, Victor Sebastian, Gracia Mendoza, Manuel Arruebo. ACS Applied Materials & Interfaces 13:17220. 2021. Q1.

- “Supramolecular functionalizable linear-dendritic block copolymers for the preparation of nanocarriers by microfluidics” Miriam Abad, Alejandro Martínez-Bueno, Gracia Mendoza, Manuel Arruebo, Luis Oriol, Victor Sebastian, Milagros Piñol. Polymers 13:684. 2021. Q1.

- “Encapsulation of large-size plasmids in PLGA nanoparticles for gene editing: Comparison of three different synthesis methods”. Tresa López-Royo, Víctor Sebastián, Laura Moreno-Martínez, Laura Uson, Cristina Yus, Teresa Alejo, Pilar Zaragoza, Rosario Osta, Manuel Arruebo, Raquel Manzano. Nanomaterials 11:2723. 2021. Q1.

- “Controlling particle size and release kinetics in the sustained delivery of oral antibiotics using pH-independent mucoadhesive polymers” Cristina Yus, Silvia Irusta, Víctor Sebastián, Manuel Arruebo. Molecular Pharmaceutics 17:3314. 2020. Q1.

- “Isolation of exosomes from whole blood by a new microfluidic device: proof of concept application in the diagnosis and monitoring of pancreatic cancer” María Sancho-Albero, Víctor Sebastián, Javier Sesé, Roberto Pazo-Cid, Gracia Mendoza, Manuel Arruebo, Pilar Martín-Duque, Jesús Santamaría. Journal of Nanobiotechnology 18:150. 2020. D1.

- “Drug-eluting wound dressings having sustained release of antimicrobial compounds” Enrique Gámez-Herrera, Sara García-Salinas, Sofía Salido, María Sancho-Albero, Vanesa Andreu, Marta Pérez, Lluís Luján, Silvia Irusta, Manuel Arruebo, Gracia Mendoza. European Journal of Pharmaceutics and Biopharmaceutics 152:327. 2020. Q1.

- “Antimicrobial wound dressings against fluorescent and methicillin-sensitive intracellular pathogenic bacteria” Sara García-Salinas, Enrique Gámez-Herrera, Guillermo Landa, Manuel Arruebo, Silvia Irusta, Gracia Mendoza. ACS Applied Materials & Interfaces 12:51302. 2020. Q1.

- “Antibacterial effect of thymol loaded SBA-15 nanorods incorporated in PCL electrospun fibers” Enrique Gámez-Herrera, Hellen Elizondo-Castillo, Jorge Tascón, Sara García-Salinas, Nuria Navascues, Gracia Mendoza, Manuel Arruebo, Silvia Irusta. Nanomaterials 10:616. 2020. Q1.

- “Novel intracellular antibiotic delivery system against Staphylococcus aureus: cloxacillin-loaded poly(d,l-lactide-co-glycolide) acid nanoparticles” Alicia Lacoma, Laura Usón, Gracia Mendoza, Víctor Sebastián, Esther García-García, Beatriz Muriel-Moreno, José Domínguez, Manuel Arruebo, Cristina Prat. Nanomedicine 15:1189 final: 1203. 2020. Q1.

- “Light-triggered nanoparticles for pain management” Gracia Mendoza, Manuel Arruebo. Expert Opinion on Drug Delivery 17:627. 2020. D1.

- “Customized hybrid and thermoresponsive drug delivery microparticles synthetized by photopolymerization in a one-step flow focusing continuous microreactor” Isabel Ortiz de Solorzano, Gracia Mendoza, Manuel Arruebo, Víctor Sebastián. Colloids and Surfaces B: Biointerfaces 190:110904. 2020. Q1.

- “Electrospun anti-inflammatory patch loaded with essential oils for wound healing” Sara García-Salinas, Michael Evangelopoulos, Enrique Gámez-Herrera, Manuel Arruebo, Silvia Irusta, Francesca Taraballi, Gracia Mendoza, Ennio Tasciotti. International Journal of Pharmaceutics 577:119067. 2020. Q1.

- “Organometallic ciprofloxacin conjugates with dual action: synthesis, characterization, and antimicrobial and cytotoxicity studies”Łukasz Szczupak, Aleksandra Kowalczyk, Damian Trzybiński, Krzysztof Woźniak, Gracia Mendoza, Manuel Arruebo, Dietmar Steverding, Paweł Stączek, Konrad Kowalski. Dalton Transactions 49:1403. 2020. Q1.

- “Triggered drug release from hybrid thermoresponsive nanoparticles using near infrared light” Isabel Ortiz de Solorzano, Martín Prieto, Gracia Mendoza, Víctor Sebastián, Manuel Arruebo. Nanomedicine 15:219. 2020. Q1.

- “Targeted release of probiotics from enteric microparticulated formulations” Cristina Yus, Ruben Gracia, Ane Larrea, Vanesa Andreu, Silvia Irusta, Victor Sebastian, Gracia Mendoza, Manuel Arruebo. Polymers 11:1668. 2019. Q1.

- “Antimicrobial electrospun polycaprolactone-based wound dressings: an in vitro study about the importance of the direct contact to elicit bactericidal activity” Enrique Gámez-Herrera, Gracia Mendoza, Sofía Salido, Manuel Arruebo, Silvia Irusta. Advances in Wound Care 8:438. 2019. Q1.

- “Exosome origin determines cell targeting and the transfer of therapeutic nanoparticles towards target cells” María Sancho-Albero, Nuria Navascués, Gracia Mendoza, Víctor Sebastián, Manuel Arruebo, Pilar Martín-Duque, Jesús Santamaría. Journal of Nanobiotechnology 17:16. 2019. D1.

- “Matryoshka-type microparticles for the oral treatment of Mycobacterium tuberculosis” Vanesa Andreu, Ane Larrea, Pablo Rodriguez-Fernandez, Salvador Alfaro, Begoña Gracia, Ainhoa, Lucía, Laura Usón, Andromeda-Celeste Gomez, Gracia Mendoza, Alicia Lacoma, Jose Dominguez, Cristina Prat, Victor Sebastian, José Antonio Ainsa, Manuel Arruebo. Nanomedicine 14:707. 2019. Q1.

- “Efficient encapsulation of theranostic nanoparticles in cell-derived exosomes: leveraging the exosomal biogenesis pathway to obtain hollow gold nanoparticle-hybrids” María Sancho-Albero, Maria Del Mar Encabo-Berzosa, Manuel Beltrán-Visiedo, Lola Fernández-Messina, Víctor Sebastián, Francisco Sánchez-Madrid, Manuel Arruebo, Jesús Santamaría, Pilar Martín-Duque. Nanoscale 11:18825. 2019. Q1.

- “Preparation and identification of optimal synthesis conditions for a novel alkaline anion-exchange membrane” Aitor Marcos-Madrazo, Clara Casado-Coterillo, Leticia García-Cruz, Jesús Iniesta, Laura Simonelli, Víctor Sebastián, María Del Mar Encabo-Berzosa, Manuel Arruebo, Ángel Irabien. Polymers 13:10. 2018. Q1.

- “Cleavable and thermo-responsive hybrid nanoparticles for on-demand drug delivery” Isabel Ortiz de Solorzano, Teresa Alejo, Miriam Abad, Carlos Bueno, Gracia Mendoza, Vanesa Andreu, Silvia Irusta, Victor Sebastian, Manuel Arruebo. Journal of Colloid and Interface Science 533:171. 2018. 2018. Q1.

- “Enzyme structure and function protection from gastrointestinal degradation using enteric coatings” Ruben Gracia, Cristina Yus, Olga Abian, Gracia Mendoza, Silvia Irusta, Victor Sebastian, Vanesa Andreu, Manuel Arruebo. International Journal of Biological Macromolecules 119 :413. 2018. D1.

- “Rapid on-chip assembly of niosomes: batch versus continuous flow reactors” Sara García-Salinas, Erico Himawan, Gracia Mendoza, Manuel Arruebo, Víctor Sebastián. ACS Applied Materials & Interfaces 10: 19197. 2018. Q1.

- “Controlled release of bupivacaine using hybrid thermoresponsive nanoparticles activated via photothermal heating” Teresa Alejo, Vanesa Andreu, Gracia Mendoza, Victor Sebastian, Manuel Arruebo. Journal of Colloid and Interface Science 523:234. 2018. Q1.

- “Near infrared dye-labeled polymeric micro- and nanomaterials: in vivo imaging and evaluation of their local persistence” Gracia Mendoza, Isabel Ortiz de Solórzano, Inmaculada Pintre, Sara García-Salinas, Victor Sebastian, Vanesa Andreu, Marina Gimeno, Manuel Arruebo. Nanoscale 10:2970. 2018. Q1.

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