Sobre el grupo
Investigador Principal
Javier Sancho Sanz
Equipo
Adrian Velázquez Campoy, Antonio Hidalgo Toledo, Helena García Cebollada, Jose Alberto Carrodeguas Villar, Juan José Galano Frutos, Patricia Bruñén Fau, Ramón Hurtado Guerrero, Ritwik Maity
Universidad de Zaragoza
Líneas de Investigación
Descubrimiento de fármacos
Interpretación genética
Fármacos biológicos, diseño y mejora de antígenos
Publicaciones más relevantes
Narimatsu Y, Bull C, Taleb V, Liao Q, Companon I, Sanchez-Navarro D, Durbesson F, Vincentelli R, Hansen L, Corzana F, Rovira C, Henrissat B, Clausen H, Joshi H, Hurtado Guerrero R. A family of di-glutamate mucin-degrading enzymes that bridges glycan hydrolases and peptidases. Nature Catalysis. 2024. 10.1038/s41929-024-01116-5. FI-42,9
Baños-Jaime B, Corrales-Guerrero L, Pérez-Mejías G, Rejano-Gordillo C, Velázquez Campoy A, Martínez-Cruz L, Martínez-Chantar M, De la Rosa M, Díaz-Moreno I. Phosphorylation at the disordered N-end makes HuR accumulate and dimerize in the cytoplasm.. NUCLEIC ACIDS RESEARCH. 2024. 10.1093/nar/gkae564. FI-16,7
Ortega Alarcón D, Claveria Gimeno R, Vega Sánchez S, Kalani L, Jorge-Torres O, Esteller M, Ausio J, Abián Franco O, Velázquez Campoy A. Extending MeCP2 interactome: canonical nucleosomal histones interact with MeCP2.. NUCLEIC ACIDS RESEARCH. 2024. 10.1093/nar/gkae051. FI-16,7
Sanz-Martinez I, Pereira S, Merino P, Corzana F, Hurtado Guerrero R. Molecular Recognition of GalNAc in Mucin-Type O-Glycosylation.. ACCOUNTS OF CHEMICAL RESEARCH. 2023. 10.1021/acs.accounts.2c00723. FI-16,7
Manabe Y, Takebe T, Kasahara S, Hizume K, Kabayama K, Kamada Y, Asakura A, Shinzaki S, Takamatsu S, Miyoshi E, Garcia-Garcia A, Vakhrushev S, Hurtado Guerrero R, Fukase K. Development of a FUT8 Inhibitor with Cellular Inhibitory Properties. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2024. 10.1002/anie.202414682. FI-16,1
Corzana F, Asín A, Eguskiza A, De Tomi E, Martín-Carnicero A, Martínez-Moral M, Mangini V, Papi F, Bretón C, Oroz P, Lagartera L, Jiménez-Moreno E, Avenoza A, Busto J, Nativi C, Asensio J, Hurtado Guerrero R, Peregrina J, Malerba G, Martínez A, Fiammengo R. Detection of Tumor-Associated Autoantibodies in the Sera of Pancreatic Cancer Patients Using Engineered MUC1 Glycopeptide Nanoparticle Probes.. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2024. 10.1002/anie.202407131. FI-16,1
Redrado-Hernández S, Macías-León J, Castro-López J, Belén Sanz A, Dolader Ballesteros E, Arias Cabrero M, González-Ramírez A, Sánchez-Navarro D, Petryk Y, Farkaš V, Vincke C, Muyldermans S, García-Barbazán I, del Agua Arias-Camisón C, Zaragoza O, Arroyo J, Pardo Jimeno J, Gálvez Buerba E, Hurtado Guerrero R. Broad Protection against Invasive Fungal Disease from a Nanobody Targeting the Active Site of Fungal ß-1,3-Glucanosyltransferases.. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2024. 10.1002/anie.202405823. FI-16,1
Sanz-Martinez I, Garcia-Garcia A, Tejero T, Hurtado Guerrero R, Merino P. The Essential Role of Water Molecules in the Reaction Mechanism of Protein O-Fucosyltransferase 2. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2022. 10.1002/anie.202213610. FI-16,1
Jaroentomeechai T, Karlsson R, Goerdeler F, Teoh F, Gronset M, de Wit D, Chen Y, Furukawa S, Psomiadou V, Hurtado Guerrero R, Vidal-Calvo E, Salanti A, Boltje T, van den Bos L, Wunder C, Johannes L, Schjoldager K, Joshi H, Miller R, Clausen H, Vakhrushev S, Narimatsu Y. Mammalian cell-based production of glycans, glycopeptides and glycomodules. Nature Communications. 2024. 10.1038/s41467-024-53738-9. FI-14,7
Piniello B, Macías-León J, Miyazaki S, García-García A, Compañón I, Ghirardello M, Taleb V, Veloz B, Corzana F, Miyagawa A, Rovira C, Hurtado Guerrero R. Molecular basis for bacterial N-glycosylation by a soluble HMW1C-like N-glycosyltransferase.. Nature Communications. 2023. 10.1038/s41467-023-41238-1. FI-14,7