Sobre el grupo
Investigador Principal
Rosario Osta Pinzolas
Equipo
Adelaida Hernaiz Martorell, Alina Cequier Soler, Ana Cristina Calvo Royo, Antonio Romero Lasheras, Carmen Cons Claver, Clementina Rodellar Penella, Cristina Iñiguez Martínez, Elisa Gascón Rodríguez, Elvira Bernad Roche, Francisco José Vázquez Bringas, Gabriel Rada Rodrigo, Inés Valledor Martín, Inmaculada Martín Burriel, Janne Markus Toivonen, Javier Miana Mena, Jorge Palacio Liesa, Laura Moreno Martínez, Leticia Moreno García, Mª Belén Serrano Pastor, María Jesús Muñoz Gonzalvo, Marta Miñana Barrios, Miriam de la Torre Sebastián, Mirta García Martínez, Nora Molina Torres, Paula Aparicio Berdejo, Pilar Larrodé Pellicer, Pilar Zaragoza Fernández, Raquel Manzano Martínez, Sara Fuente Franco, Tresa Iguázel López Royo
Universidad de Zaragoza
Líneas de Investigación
Caracterización de células madre adultas en modelos de neurodegeneración.
Desarrollo de biomarcadores en enfermedades que afectan al Sistema Nervioso Central (genómicos, genéticos y proteómicos)
Terapia celular en enfermedades que afectan a la degeneración de la neurona motora en modelos animales (ratones)
Terapia génica no viral en enfermedades que afectan al Sistema Nervioso Central
Terapia regenerativa en modelos animales
Terapia regenerativa experimental en modelos animales de mediano y gran tamaño (perros, ovejas y caballos)
Publicaciones más relevantes
Gomez-Vallejo J, Albareda-Albareda J, Seral-Garcia B, Blanco-Rubio N, Ezquerra-Herrando L. Revision total knee arthroplasty: hybrid vs standard cemented fixation. J Orthop Traumatol. 2018. 19(1): UNSP 9. 10.1186/s10195-018-0494-y.
Sevane N, Cortes O, Gama L, Martinez A, Zaragoza P, Amills M, Bedotti D, de Sousa C, Canon J, Dunner S, Ginja C, Lanari M, Landi V, Sponenberg P, Delgado J, BioGoat Consortium. Dissection of ancestral genetic contributions to Creole goat populations. Animal. 2018. 12(10): 2017 - 2026. 10.1017/S1751731117003627.
Barrachina L, Remacha A, Romero A, Vitoria A, Albareda J, Prades M, Roca M, Zaragoza P, Vazquez F, Rodellar C. Assessment of effectiveness and safety of repeat administration of proinflammatory primed allogeneic mesenchymal stem cells in an equine model of chemically induced osteoarthritis. BMC Vet. Res.. 2018. 14: 241. 10.1186/s12917-018-1556-3.
Barrachina L, Romero A, Zaragoza P, Rodellar C, Vazquez F. Practical considerations for clinical use of mesenchymal stem cells: From the laboratory to the horse. Vet. J.. 2018. 238: 49 - 57. 10.1016/j.tvjl.2018.07.004.
Sanz-Rubio D, Martin-Burriel I, Gil A, Cubero P, Forner M, Khalyfa A, Marin J. Stability of Circulating Exosomal miRNAs in Healthy Subjects. Sci Rep. 2018. 8: 10306. 10.1038/s41598-018-28748-5.
Gimeno M, Pinczowski P, Mendoza G, Asin J, Vazquez F, Vispe E, Garcia-Alvarez F, Perez M, Santamaria J, Arruebo M, Lujan L. Antibiotic-eluting orthopedic device to prevent early implant associated infections: Efficacy, biocompatibility and biodistribution studies in an ovine model. J. Biomed. Mater. Res. Part B. 2018. 106(5): 1976 - 1986. 10.1002/jbm.b.34009.
Otero A, Bolea R, Hedman C, Fernandez-Borges N, Marin B, Lopez-Perez O, Barrio T, Erana H, Sanchez-Martin M, Monzon M, Badiola J, Castilla J. An Amino Acid Substitution Found in Animals with Low Susceptibility to Prion Diseases Confers a Protective Dominant-Negative Effect in Prion-Infected Transgenic Mice. Mol. Neurobiol.. 2018. 55(7): 6182 - 6192. 10.1007/s12035-017-0832-8.
Blain A, Greally E, McClorey G, Manzano R, Bette C, Godfrey C, O'Donovan L, Coursindel T, Gait M, Wood M, MacGowan G, Straub V. Peptide-conjugated phosphodiamidate oligomer-mediated exon skipping has benefits for cardiac function in mdx and Cmah-/-mdx mouse models of Duchenne muscular dystrophy. PLoS One. 2018. 13(6): e0198897. 10.1371/journal.pone.0198897.
Barrachina L, Remacha A, Romero A, Zaragoza P, Vazquez F, Rodellar C. Differentiation of equine bone marrow derived mesenchymal stem cells increases the expression of immunogenic genes. Vet Immunol Immunopathol. 2018. 200: 1 - 6. 10.1016/j.vetimm.2018.04.004.
Molin J, Asin J, Vitoria A, Sanz A, Gimeno M, Romero A, Sanchez J, Pinczowski P, Vazquez F, Rodellar C, Lujan L. Congenital Hepatic Fibrosis in a Purebred Spanish Horse Foal: Pathology and Genetic Studies on PKHD1 Gene Mutations. Vet. Pathol.. 2018. 55(3): 457 - 461. 10.1177/0300985817754122.
Rando A, Pastor D, Viso-Leon M, Martinez A, Manzano R, Navarro X, Osta R, Martinez S. Intramuscular transplantation of bone marrow cells prolongs the lifespan of SOD1(G93A) mice and modulates expression of prognosis biomarkers of the disease. Stem Cell Res. Ther.. 2018. 9: 90. 10.1186/s13287-018-0843-z.
Martin-Hernandez C, Sanz-Sainz M, Revenga-Giertych C, Hernandez-Vaquero D, Fernandez-Carreira J, Albareda-Albareda J, Castillo-Palacios A, Ranera-Garcia M. Navigated versus conventional total knee arthroplasty: A prospective study at three years follow-up.. Rev Esp Cir Ortop Traumatol. 2018. . 10.1016/j.recot.2018.01.001.
Andres-Lasheras S, Martin-Burriel I, Mainar-Jaime R, Morales M, Kuijper E, Blanco J, Chirino-Trejo M, Bolea R. Preliminary studies on isolates of Clostridium difficile from dogs and exotic pets. BMC Vet. Res.. 2018. 14: 77. 10.1186/s12917-018-1402-7.
Sierra M, Bragg-Gonzalo L, Grasa J, Munoz M, Gonzalez D, Miana-Mena F. Oxidative stress prediction: A preliminary approach using a response surface based technique. Toxicol. Vitro. 2018. 46: 273 - 283. 10.1016/j.tiv.2017.10.016.
Silva C, Erickson-Beltran M, Martin-Burriel I, Badiola J, Requena J, Bolea R. Determining the Relative Susceptibility of Four Prion Protein Genotypes to Atypical Scrapie. Anal. Chem.. 2018. 90(2): 1255 - 1262. 10.1021/acs.analchem.7b03985.