Chan Zuckerberg Initiative – Implementation of Synthetic Biology Principles in Immunology

Chan Zuckerberg Biohub Network and the Chan Zuckerberg Initiative invite applications for two-year initial research projects that harness synthetic biology to revolutionize our understanding and treatment of immune-related disorders. This RFA represents a strategic investment in transformative research that has the potential to yield breakthroughs with far-reaching impact on public health.

Eligibility:

• Applications may be submitted by domestic and foreign nonprofit organizations, including public and private institutions, such as colleges, universities, hospitals, laboratories, units of state and local government, and eligible agencies of the federal government.
• An organization may submit more than one application.
• Each application should designate one Principal Investigator as the Coordinating Principal Investigator. The Coordinating PI will act as the administrative contact between us and all other PIs on the grant (Co-PIs). The grant funds will be awarded to the institution submitting the application, and grant funds will be awarded to that institution, which will take responsibility for distributing funds to any other institution.
• Teams may include a total of three PIs
• PIs may only apply to join and serve as Coordinating PI or Co-PI on one application. Participation in multiple projects as an unfunded collaborator is allowed and encouraged.
• PIs and Co-PIs on one application may be employed at the same or different institutions
• PIs and Co-PIs must each be permitted to receive grant support from the organization they are applying with. This criterion may be defined differently in different types of organizations.
• Early career investigators are strongly encouraged to apply as Coordinating PIs and Co-PIs
• Meta employees, including employees of any subsidiary Meta entities, as well as employees of Chan Zuckerberg Initiative, LLC and Chan Zuckerberg Biohub, Inc., are not permitted to apply.
• CZI and the Biohub Network reserve the right to decide if an applicant and their organization meet the eligibility requirements.
• CZI and the Biohub reserve the right to request budget changes prior to award.
• Applications from any country are welcomed provided the proposed work is compliant with the United States Treasury Department’s Office of Foreign Asset Control (OFAC) sanctions program.

Applications due 13 November 2025, by 2 pm PT / 5 pm ET