IpIBA seminar series 2022/2023 “IpIBA seminar series 2022/2023 “Role of adipose tissue in the properties of pancreatic cancer stem cells”
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers nowadays, partly due to the intrinsic aggressiveness and chemoresistance of the cancer stem cell (CSC) subpopulation. Pancreatic CSCs metabolism depends on oxidative phosphorylation, allowing them to use a range of substrates, including fatty acids (FAs). Adipocytes from the tumour microenvironment influence cancer cell growth and metabolism in several tumour types, providing FAs and signals via cytokines. Since increased lipid scavenging and aberrant FA metabolism have been linked to tumour progression in PDAC patients, our aim is to study the communication between adipocytes and CSCs in PDAC. Although preliminary, our results suggest an active interplay between adipocytes and CSCs, potentially representing a novel mechanism by which the pancreatic tumour microenvironment favors the aggressive phenotype of CSCs in PDAC.
CIBA, main metting room and online via zoom.